BDBM50060471 4-Chloro-5,6-dihydro-benzo[c]acridin-7-ylamine::CHEMBL333011

SMILES: Nc1c2CCc3c(Cl)cccc3-c2nc2ccccc12

InChI Key: InChIKey=WTSAZZJEZMYESQ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50060471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50060471 (4-Chloro-5,6-dihydro-benzo[c]acridin-7-ylamine | C...) Show SMILES Nc1c2CCc3c(Cl)cccc3-c2nc2ccccc12 Show InChI InChI=1S/C17H13ClN2/c18-14-6-3-5-11-10(14)8-9-13-16(19)12-4-1-2-7-15(12)20-17(11)13/h1-7H,8-9H2,(H2,19,20)	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Strathclyde Curated by ChEMBL					Assay Description Inhibition of neuronal uptake of Noradrenaline in rat brain homogenate				J Med Chem 40: 3516-23 (1997) Article DOI: 10.1021/jm970150t BindingDB Entry DOI: 10.7270/Q25H7FC9
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50060471 (4-Chloro-5,6-dihydro-benzo[c]acridin-7-ylamine | C...) Show SMILES Nc1c2CCc3c(Cl)cccc3-c2nc2ccccc12 Show InChI InChI=1S/C17H13ClN2/c18-14-6-3-5-11-10(14)8-9-13-16(19)12-4-1-2-7-15(12)20-17(11)13/h1-7H,8-9H2,(H2,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.44E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Strathclyde Curated by ChEMBL					Assay Description In vitro inhibition of acetylcholinesterase, isolated from rat brain.				J Med Chem 40: 3516-23 (1997) Article DOI: 10.1021/jm970150t BindingDB Entry DOI: 10.7270/Q25H7FC9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50060471 (4-Chloro-5,6-dihydro-benzo[c]acridin-7-ylamine | C...) Show SMILES Nc1c2CCc3c(Cl)cccc3-c2nc2ccccc12 Show InChI InChI=1S/C17H13ClN2/c18-14-6-3-5-11-10(14)8-9-13-16(19)12-4-1-2-7-15(12)20-17(11)13/h1-7H,8-9H2,(H2,19,20)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Strathclyde Curated by ChEMBL					Assay Description Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenate				J Med Chem 40: 3516-23 (1997) Article DOI: 10.1021/jm970150t BindingDB Entry DOI: 10.7270/Q25H7FC9
					More data for this Ligand-Target Pair
Cholinesterases (Homo sapiens (Human))	BDBM50060471 (4-Chloro-5,6-dihydro-benzo[c]acridin-7-ylamine | C...) Show SMILES Nc1c2CCc3c(Cl)cccc3-c2nc2ccccc12 Show InChI InChI=1S/C17H13ClN2/c18-14-6-3-5-11-10(14)8-9-13-16(19)12-4-1-2-7-15(12)20-17(11)13/h1-7H,8-9H2,(H2,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Strathclyde Curated by ChEMBL					Assay Description In vitro inhibition of Butyrylcholinesterase from human plasma.				J Med Chem 40: 3516-23 (1997) Article DOI: 10.1021/jm970150t BindingDB Entry DOI: 10.7270/Q25H7FC9
					More data for this Ligand-Target Pair