BDBM50060688 7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline::7-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline::CHEMBL341474
SMILES: CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
InChI Key: InChIKey=RYXJSAHVNPQLMV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Serotonin (5-HT) receptor (RAT) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development Curated by ChEMBL | Assay Description Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate | J Med Chem 52: 3548-62 (2009) Article DOI: 10.1021/jm900018b BindingDB Entry DOI: 10.7270/Q2M908K7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (RAT) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development Curated by ChEMBL | Assay Description Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate | J Med Chem 52: 6946-50 (2009) Article DOI: 10.1021/jm901126m BindingDB Entry DOI: 10.7270/Q2H9963M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 124 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex | J Med Chem 52: 3548-62 (2009) Article DOI: 10.1021/jm900018b BindingDB Entry DOI: 10.7270/Q2M908K7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 138 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development Curated by ChEMBL | Assay Description Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus | J Med Chem 52: 3548-62 (2009) Article DOI: 10.1021/jm900018b BindingDB Entry DOI: 10.7270/Q2M908K7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (GUINEA PIG) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatum | J Med Chem 52: 3548-62 (2009) Article DOI: 10.1021/jm900018b BindingDB Entry DOI: 10.7270/Q2M908K7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate. | J Med Chem 40: 3670-8 (1997) Article DOI: 10.1021/jm970376w BindingDB Entry DOI: 10.7270/Q24Q7VP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2A receptor | J Med Chem 40: 3670-8 (1997) Article DOI: 10.1021/jm970376w BindingDB Entry DOI: 10.7270/Q24Q7VP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (RAT) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Inhibition of radiolabeled [3H]GR-113808 ligand binding to 5-hydroxytryptamine 4 receptor | J Med Chem 40: 3670-8 (1997) Article DOI: 10.1021/jm970376w BindingDB Entry DOI: 10.7270/Q24Q7VP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 413 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptor | J Med Chem 40: 3670-8 (1997) Article DOI: 10.1021/jm970376w BindingDB Entry DOI: 10.7270/Q24Q7VP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1B/1D receptor (Rattus norvegicus (Rat)) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 371 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor | J Med Chem 40: 3670-8 (1997) Article DOI: 10.1021/jm970376w BindingDB Entry DOI: 10.7270/Q24Q7VP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR3A (GUINEA PIG) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development Curated by ChEMBL | Assay Description Agonist activity at 5HT3 receptor in voltage-stimulated guinea pig left atrium assessed as positive inotropic potency | J Med Chem 52: 6946-50 (2009) Article DOI: 10.1021/jm901126m BindingDB Entry DOI: 10.7270/Q2H9963M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Homo sapiens (Human)) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Universita' degli Studi di Salerno Curated by ChEMBL | Assay Description Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells. | J Med Chem 42: 4362-79 (1999) BindingDB Entry DOI: 10.7270/Q2S75FJM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' degli Studi di Salerno Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand | J Med Chem 42: 4362-79 (1999) BindingDB Entry DOI: 10.7270/Q2S75FJM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50060688 (7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptor | J Med Chem 40: 3670-8 (1997) Article DOI: 10.1021/jm970376w BindingDB Entry DOI: 10.7270/Q24Q7VP2 | |||||||||||
More data for this Ligand-Target Pair |