BDBM50061056 CHEMBL3393542::US9732087, 73
SMILES: CCCCNc1nccc(n1)N1CC[C@H](C1)NC
InChI Key: InChIKey=FMAHIXYZGXPWMZ-LLVKDONJSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50061056 (CHEMBL3393542 | US9732087, 73) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA N.V. US Patent | Assay Description Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa... | US Patent US9732087 (2017) BindingDB Entry DOI: 10.7270/Q2251M9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50061056 (CHEMBL3393542 | US9732087, 73) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor | Bioorg Med Chem Lett 25: 956-9 (2015) Article DOI: 10.1016/j.bmcl.2014.12.027 BindingDB Entry DOI: 10.7270/Q2639RDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50061056 (CHEMBL3393542 | US9732087, 73) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL | Assay Description Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor... | Bioorg Med Chem Lett 25: 956-9 (2015) Article DOI: 10.1016/j.bmcl.2014.12.027 BindingDB Entry DOI: 10.7270/Q2639RDD | |||||||||||
More data for this Ligand-Target Pair |