BDBM50061572 1-(2,6-Difluoro-benzyl)-2-phenyl-1H-benzoimidazole::1-(2,6-difluorobenzyl)-2-phenyl-1H-benzo[d]imidazole::CHEMBL57772
SMILES: Fc1cccc(F)c1Cn1c(nc2ccccc12)-c1ccccc1
InChI Key: InChIKey=KBOHDHODCNDQPB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50061572 (1-(2,6-Difluoro-benzyl)-2-phenyl-1H-benzoimidazole...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.06E+3 | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Inhibition of HIV-1 reverse transcriptase. | J Med Chem 46: 1940-7 (2003) Article DOI: 10.1021/jm020271f BindingDB Entry DOI: 10.7270/Q2610ZPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50061572 (1-(2,6-Difluoro-benzyl)-2-phenyl-1H-benzoimidazole...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Cancer Research and Development Center Curated by ChEMBL | Assay Description The quantity of compound required to reduce WT Reverse transcriptase activity by 50% | J Med Chem 40: 4199-207 (1998) Article DOI: 10.1021/jm970096g BindingDB Entry DOI: 10.7270/Q25B01KN | |||||||||||
More data for this Ligand-Target Pair |