BDBM50061899 2',5'-Dimethyl-3'-(phenylmethyl)spiro[cyclopentane1,7'(8'H)-[2H]imidazol[1,2-a]pyrzolo[4,3-e]pyrimidin]-4'-(5'H)-one::CHEMBL137400
SMILES: CN1C2=NC3(CCCC3)CN2c2nn(C)c(Cc3ccccc3)c2C1=O
InChI Key: InChIKey=FDOVMJSEGUQXQX-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase (Bos taurus) | BDBM50061899 (2',5'-Dimethyl-3'-(phenylmethyl)spiro[cyclopentane...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Inhibition of Phosphodiesterase 3 from bovine heart | J Med Chem 40: 4372-7 (1998) Article DOI: 10.1021/jm970495b BindingDB Entry DOI: 10.7270/Q2833R45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-dependent 3',5'-cyclic phosphodiesterase (Bos taurus) | BDBM50061899 (2',5'-Dimethyl-3'-(phenylmethyl)spiro[cyclopentane...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Inhibition of Phosphodiesterase 2 from bovine adrenal cortex | J Med Chem 40: 4372-7 (1998) Article DOI: 10.1021/jm970495b BindingDB Entry DOI: 10.7270/Q2833R45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus) | BDBM50061899 (2',5'-Dimethyl-3'-(phenylmethyl)spiro[cyclopentane...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Inhibition of phosphodiesterase 5 from bovine lung | J Med Chem 40: 4372-7 (1998) Article DOI: 10.1021/jm970495b BindingDB Entry DOI: 10.7270/Q2833R45 | |||||||||||
More data for this Ligand-Target Pair |