BindingDB PrimarySearch

BDBM50062415 5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL102754

SMILES: CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4ccc(Cl)c(F)c4)c3c12

InChI Key: InChIKey=WNRXXFMGMKLIHP-UHFFFAOYSA-N

Data: 3 KI 4 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50062415
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description The binding affinity of the compound was determined on Human progesterone receptor (hPR-A) using progesterone as radioligand.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity was determined on Human glucocorticoid receptor (hAR) using progesterone as radioligand.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity was determined on Human androgen receptor (hAR) using progesterone as radioligand.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Agonistic activity to the human progesterone receptor(hPR)assayed in CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	171	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human glucocorticoid receptor(hGR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human progesterone receptor(hPR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50062415 (5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-d...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human androgen receptor(hAR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair