BDBM50062421 5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL102541

SMILES: CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12

InChI Key: InChIKey=DTIMQMAYRMJPRM-UHFFFAOYSA-N

Data: 3 KI  4 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50062421   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description The binding affinity of the compound was determined on Human progesterone receptor (hPR-A) using progesterone as radioligand.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity was determined on Human glucocorticoid receptor (hAR) using progesterone as radioligand.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.58E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity was determined on Human androgen receptor (hAR) using progesterone as radioligand.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Agonistic activity to the human progesterone receptor(hPR)assayed in CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human glucocorticoid receptor(hGR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human progesterone receptor(hPR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50062421 (5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydr...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4cc(Cl)cc(Cl)c4)c3c12 |t:1| Show InChI InChI=1S/C25H21Cl2NO/c1-14-13-25(2,3)28-20-9-8-19-18-6-4-5-7-21(18)29-24(23(19)22(14)20)15-10-16(26)12-17(27)11-15/h4-13,24,28H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity was determined in Human androgen receptor(hAR) of CV-1 cells in cotransfection assay.				J Med Chem 41: 291-302 (1998) Article DOI: 10.1021/jm9705768 BindingDB Entry DOI: 10.7270/Q29W0DMD
					More data for this Ligand-Target Pair