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BDBM50062644 2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide::CHEMBL134576

SMILES: FC(F)(F)c1[nH]c(=O)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=WAOXRUWLDSCAIB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50062644   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activating transcription factor 1


(Homo sapiens (Human))
BDBM50062644
PNG
(2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxyli...)
Show SMILES FC(F)(F)c1[nH]c(=O)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C12H6Cl2F3N3O2/c13-5-1-6(14)3-7(2-5)19-10(21)8-4-18-11(22)20-9(8)12(15,16)17/h1-4H,(H,19,21)(H,18,20,22)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1


J Med Chem 41: 413-9 (1998)


Article DOI: 10.1021/jm970671g
BindingDB Entry DOI: 10.7270/Q2P55MMZ
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062644
PNG
(2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxyli...)
Show SMILES FC(F)(F)c1[nH]c(=O)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C12H6Cl2F3N3O2/c13-5-1-6(14)3-7(2-5)19-10(21)8-4-18-11(22)20-9(8)12(15,16)17/h1-4H,(H,19,21)(H,18,20,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


J Med Chem 41: 413-9 (1998)


Article DOI: 10.1021/jm970671g
BindingDB Entry DOI: 10.7270/Q2P55MMZ
More data for this
Ligand-Target Pair