BDBM50062662 2-Cyclohexylamino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide::CHEMBL134876

SMILES: FC(F)(F)c1nc(NC2CCCCC2)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=UJEMQSTUVYRJHK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50062662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM50062662 (2-Cyclohexylamino-4-trifluoromethyl-pyrimidine-5-c...) Show SMILES FC(F)(F)c1nc(NC2CCCCC2)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C18H17Cl2F3N4O/c19-10-6-11(20)8-13(7-10)25-16(28)14-9-24-17(27-15(14)18(21,22)23)26-12-4-2-1-3-5-12/h6-9,12H,1-5H2,(H,25,28)(H,24,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair
Activating transcription factor 1 (Homo sapiens (Human))	BDBM50062662 (2-Cyclohexylamino-4-trifluoromethyl-pyrimidine-5-c...) Show SMILES FC(F)(F)c1nc(NC2CCCCC2)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C18H17Cl2F3N4O/c19-10-6-11(20)8-13(7-10)25-16(28)14-9-24-17(27-15(14)18(21,22)23)26-12-4-2-1-3-5-12/h6-9,12H,1-5H2,(H,25,28)(H,24,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair