BDBM50062673 2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (5-methyl-thiophen-2-yl)-amide::CHEMBL134990

SMILES: Cc1ccc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)s1

InChI Key: InChIKey=PIMXIBRTRAINKM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50062673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM50062673 (2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES Cc1ccc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)s1 Show InChI InChI=1S/C11H7ClF3N3OS/c1-5-2-3-7(20-5)17-9(19)6-4-16-10(12)18-8(6)11(13,14)15/h2-4H,1H3,(H,17,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair
Activating transcription factor 1 (Homo sapiens (Human))	BDBM50062673 (2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES Cc1ccc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)s1 Show InChI InChI=1S/C11H7ClF3N3OS/c1-5-2-3-7(20-5)17-9(19)6-4-16-10(12)18-8(6)11(13,14)15/h2-4H,1H3,(H,17,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair