BDBM50063676 CHEMBL3397325

SMILES: N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)NCc1cnn(c1)-c1ccc(F)cc1

InChI Key: InChIKey=ITCAMHKBWAUSKR-IKEGABRUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50063676   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50063676 (CHEMBL3397325) Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)NCc1cnn(c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H28FN9O4S/c25-14-1-3-15(4-2-14)34-9-13(8-32-34)7-28-23(37)16(26)5-6-39-10-17-19(35)20(36)24(38-17)33-12-31-18-21(27)29-11-30-22(18)33/h1-4,8-9,11-12,16-17,19-20,24,35-36H,5-7,10,26H2,(H,28,37)(H2,27,29,30)/t16-,17+,19+,20+,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminally FLAG-tagged wild type EZH2 in EZH2/SUZ12/EED/RbAp48 complex (unknown origin) expressed in baculovirus infected in SF9 cell...				Bioorg Med Chem Lett 25: 1532-7 (2015) Article DOI: 10.1016/j.bmcl.2015.02.017 BindingDB Entry DOI: 10.7270/Q2TM7CSS
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