BDBM50063677 CHEMBL3397324

SMILES: Cc1ccccc1-n1cc(CNC(=O)[C@@H](N)CCSC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)cn1

InChI Key: InChIKey=CQBDBWQIYIAYAB-IFHDOPEGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50063677   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50063677 (CHEMBL3397324) Show SMILES Cc1ccccc1-n1cc(CNC(=O)[C@@H](N)CCSC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)cn1 |r| Show InChI InChI=1S/C25H31N9O4S/c1-14-4-2-3-5-17(14)34-10-15(9-32-34)8-28-24(37)16(26)6-7-39-11-18-20(35)21(36)25(38-18)33-13-31-19-22(27)29-12-30-23(19)33/h2-5,9-10,12-13,16,18,20-21,25,35-36H,6-8,11,26H2,1H3,(H,28,37)(H2,27,29,30)/t16-,18+,20+,21+,25+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminally FLAG-tagged wild type EZH2 in EZH2/SUZ12/EED/RbAp48 complex (unknown origin) expressed in baculovirus infected in SF9 cell...				Bioorg Med Chem Lett 25: 1532-7 (2015) Article DOI: 10.1016/j.bmcl.2015.02.017 BindingDB Entry DOI: 10.7270/Q2TM7CSS
					More data for this Ligand-Target Pair