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BDBM50063698 4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester::4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester(FUT-175)::CHEMBL273264::Nafamostat
SMILES: [#7]\[#6](-[#7])=[#7]/c1ccc(cc1)-[#6](=O)-[#8]-c1ccc2cc(ccc2c1)-[#6](-[#7])=[#7]
InChI Key: InChIKey=MQQNFDZXWVTQEH-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Matriptase (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of matriptase (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assay | ACS Med Chem Lett 5: 1219-24 (2014) Article DOI: 10.1021/ml500254r BindingDB Entry DOI: 10.7270/Q2VM4DV8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Matriptase (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assay | Bioorg Med Chem 23: 2328-43 (2015) Article DOI: 10.1016/j.bmc.2015.03.072 BindingDB Entry DOI: 10.7270/Q23F4RB4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepsin (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assay | ACS Med Chem Lett 5: 1219-24 (2014) Article DOI: 10.1021/ml500254r BindingDB Entry DOI: 10.7270/Q2VM4DV8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepsin (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of hepsin (unknown origin) using Boc-QAR-AMC as substrate after 30 mins prior to substrate addition by fluorescence assay | Bioorg Med Chem 23: 2328-43 (2015) Article DOI: 10.1016/j.bmc.2015.03.072 BindingDB Entry DOI: 10.7270/Q23F4RB4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepatocyte growth factor activator (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of recombinant HGFA (unknown origin) using Boc-QLR-AMC as substrate by chromogenic proteolytic assay | ACS Med Chem Lett 5: 1219-24 (2014) Article DOI: 10.1021/ml500254r BindingDB Entry DOI: 10.7270/Q2VM4DV8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepatocyte growth factor activator (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu... | Bioorg Med Chem 23: 2328-43 (2015) Article DOI: 10.1016/j.bmc.2015.03.072 BindingDB Entry DOI: 10.7270/Q23F4RB4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Plasminogen (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of human plasmin assessed as reduction in hydrolytic activity using TAME as substrate after 5 mins by spectrophotometric method | J Med Chem 63: 1445-1472 (2020) Article DOI: 10.1021/acs.jmedchem.9b01060 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepatocyte growth factor activator (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to crom... | Bioorg Med Chem 23: 2328-43 (2015) Article DOI: 10.1016/j.bmc.2015.03.072 BindingDB Entry DOI: 10.7270/Q23F4RB4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Integrin alpha-2/beta-3 (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine Curated by ChEMBL | Assay Description Antagonist activity against integrin alpha2bbeta3 in human platelet rich plasma | J Med Chem 58: 7681-94 (2015) BindingDB Entry DOI: 10.7270/Q2QN68MB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Trypsin-1 (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Trypsin. | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1s (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against C1s serine protease . | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prothrombin (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Thrombin. | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Plasminogen (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against plasmin. | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prothrombin (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Inhibitory concentration against thrombin | J Med Chem 43: 305-41 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2JD4XH4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Plasminogen (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Inhibitory concentration against plasmin | J Med Chem 43: 305-41 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2JD4XH4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Inhibitory concentration against cathepsin | J Med Chem 43: 305-41 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2JD4XH4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor X (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 2.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Inhibitory concentration against Coagulation factor X | J Med Chem 43: 305-41 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2JD4XH4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against C1r serine protease | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against C1r serine protease | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against C1r serine protease | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description In vitro inhibition of purified human C1r protease. | Bioorg Med Chem Lett 9: 815-20 (1999) BindingDB Entry DOI: 10.7270/Q29G5M0K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Strathclyde Curated by ChEMBL | Assay Description Antagonist activity at integrin alpha2b beta3 receptor in citrated human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregat... | J Med Chem 60: 3241-3251 (2017) Article DOI: 10.1021/acs.jmedchem.6b01711 BindingDB Entry DOI: 10.7270/Q29W0HZ4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepsin (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Helsinki Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo... | J Med Chem 61: 4335-4347 (2018) Article DOI: 10.1021/acs.jmedchem.7b01698 BindingDB Entry DOI: 10.7270/Q2FF3VVT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Inhibition of human serum C1r using AAME as substrate after 30 mins | J Med Chem 61: 3253-3276 (2018) Article DOI: 10.1021/acs.jmedchem.7b00882 BindingDB Entry DOI: 10.7270/Q2MK6GJ9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1s (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Inhibition of human serum C1s using AGLME as substrate after 30 mins | J Med Chem 61: 3253-3276 (2018) Article DOI: 10.1021/acs.jmedchem.7b00882 BindingDB Entry DOI: 10.7270/Q2MK6GJ9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepatocyte growth factor activator (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 490 | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of HGFA in human MDA-MB-231 cells assessed as inhibition of c-MET phosphorylation after 15 mins by immunoblotting | ACS Med Chem Lett 5: 1219-24 (2014) Article DOI: 10.1021/ml500254r BindingDB Entry DOI: 10.7270/Q2VM4DV8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Trypsin-1 (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description In vitro for inhibition of purified bovine trypsin. | Bioorg Med Chem Lett 9: 815-20 (1999) BindingDB Entry DOI: 10.7270/Q29G5M0K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r subcomponent (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description The compound was evaluated to inhibit 50% of Clr Serine Protease after 60 mins and is expressed in IC50 (microM). | J Med Chem 41: 1060-7 (1998) Article DOI: 10.1021/jm970394d BindingDB Entry DOI: 10.7270/Q2PZ57ZT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Trypsin (Bos taurus (bovine)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description The compound was evaluated to inhibit trypsinand is expressed in IC50 (The concentration required to inhibit 50% of the enzyme). | J Med Chem 41: 1060-7 (1998) Article DOI: 10.1021/jm970394d BindingDB Entry DOI: 10.7270/Q2PZ57ZT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r subcomponent (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrate | J Med Chem 41: 1060-7 (1998) Article DOI: 10.1021/jm970394d BindingDB Entry DOI: 10.7270/Q2PZ57ZT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kallikrein-1 (KLK1) (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Kallikrein. | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r subcomponent (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Evaluated in vitro for inhibitory activity against purified human C1r protease incubated in buffer for 60 minutes | Bioorg Med Chem Lett 9: 815-20 (1999) BindingDB Entry DOI: 10.7270/Q29G5M0K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C1r subcomponent (Homo sapiens (Human)) | BDBM50063698 (4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against C1r serine protease | Bioorg Med Chem Lett 6: 679-682 (1996) Article DOI: 10.1016/0960-894X(96)00094-7 BindingDB Entry DOI: 10.7270/Q2P84BVF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
