BDBM50064106 CGS-26303::CHEMBL290698::{[(R)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid::{[(S)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid::{[(S)-2-Biphenyl-4-yl-1-(2H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid::{[2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid(CGS 26303)
SMILES: OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1
InChI Key: InChIKey=UUMKQZVEZSXWBY-HNNXBMFYSA-N
Data: 9 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neutral Endopeptidase (NEP) (Rattus norvegicus (Rat)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 0.930 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP) | Bioorg Med Chem Lett 5: 145-150 (1995) Article DOI: 10.1016/0960-894X(94)00474-T BindingDB Entry DOI: 10.7270/Q2G160SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutral Endopeptidase (NEP) (Rattus norvegicus (Rat)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against neutral endopeptidase at 30 mg/kg dose | Bioorg Med Chem Lett 5: 151-154 (1995) Article DOI: 10.1016/0960-894X(94)00475-U BindingDB Entry DOI: 10.7270/Q2B85831 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-converting enzyme 1 (ECE) (Rattus norvegicus (Rat)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against endothelin-converting enzyme | Bioorg Med Chem Lett 5: 151-154 (1995) Article DOI: 10.1016/0960-894X(94)00475-U BindingDB Entry DOI: 10.7270/Q2B85831 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition against recombinant human Endothelin converting enzyme 1 activity | Bioorg Med Chem Lett 7: 1059-1064 (1997) Article DOI: 10.1016/S0960-894X(97)00159-5 BindingDB Entry DOI: 10.7270/Q2WH2QGK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutral Endopeptidase (NEP) (Rattus norvegicus (Rat)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Research Curated by ChEMBL | Assay Description In vitro inhibition of rat neutral endopeptidase | J Med Chem 43: 488-504 (2000) BindingDB Entry DOI: 10.7270/Q21G0MZR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharmaceuticals Corporation Curated by ChEMBL | Assay Description Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1). | J Med Chem 41: 1513-23 (1998) Article DOI: 10.1021/jm970787c BindingDB Entry DOI: 10.7270/Q2PV6M1M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharmaceuticals Corporation Curated by ChEMBL | Assay Description Inhibitory activity against neutral endopeptidase (NEP). | J Med Chem 41: 1513-23 (1998) Article DOI: 10.1021/jm970787c BindingDB Entry DOI: 10.7270/Q2PV6M1M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Research Curated by ChEMBL | Assay Description In Vitro inhibition of recombinant human endothelin converting enzyme-1 | J Med Chem 43: 488-504 (2000) BindingDB Entry DOI: 10.7270/Q21G0MZR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50064106 (CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of neutral endopeptidase 24.11(NEP) | Bioorg Med Chem Lett 7: 1059-1064 (1997) Article DOI: 10.1016/S0960-894X(97)00159-5 BindingDB Entry DOI: 10.7270/Q2WH2QGK | |||||||||||
More data for this Ligand-Target Pair |