null
SMILES: CO\C(=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1)C(=O)NC1CC(C)(C)NC(C)(C)C1
InChI Key: InChIKey=HEUAKNQPRZZHJT-ORIKXAIESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
V-type proton ATPase 116 kDa subunit a 1 (Gallus gallus) | BDBM50064182 ((2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-p...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham S.p.A. Curated by ChEMBL | Assay Description Compound was tested for inhibititon of V-ATPase from Chicken osteoclasts(cOc) | J Med Chem 41: 1568-73 (1998) Article DOI: 10.1021/jm9800144 BindingDB Entry DOI: 10.7270/Q2CJ8CM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vacuolar proton pump subunit B (Gallus gallus) | BDBM50064182 ((2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-p...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D M£lndal Curated by ChEMBL | Assay Description Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary bone | Bioorg Med Chem Lett 10: 503-7 (2000) BindingDB Entry DOI: 10.7270/Q2542P4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
V-type proton ATPase subunit B, kidney isoform (Homo sapiens (Human)) | BDBM50064182 ((2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham S.p.A. Curated by ChEMBL | Assay Description Compound was tested for inhibititon of V-ATPase from human kidney cortex(hK) | J Med Chem 41: 1568-73 (1998) Article DOI: 10.1021/jm9800144 BindingDB Entry DOI: 10.7270/Q2CJ8CM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
V-type proton ATPase 116 kDa subunit a 1 (Gallus gallus) | BDBM50064182 ((2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-p...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham S.p.A. Curated by ChEMBL | Assay Description Compound was tested for inhibititon of V-ATPase from Chicken adrenal glands(cAG) | J Med Chem 41: 1568-73 (1998) Article DOI: 10.1021/jm9800144 BindingDB Entry DOI: 10.7270/Q2CJ8CM6 | |||||||||||
More data for this Ligand-Target Pair |