BDBM50064474 CHEMBL3401204

SMILES: Fc1ccc(cc1)N1CCc2nc(COc3ccccc3)c(Cl)n2C1=O

InChI Key: InChIKey=DRXSBJILZHMYIN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50064474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50064474 (CHEMBL3401204) Show SMILES Fc1ccc(cc1)N1CCc2nc(COc3ccccc3)c(Cl)n2C1=O Show InChI InChI=1S/C19H15ClFN3O2/c20-18-16(12-26-15-4-2-1-3-5-15)22-17-10-11-23(19(25)24(17)18)14-8-6-13(21)7-9-14/h1-9H,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assay				Bioorg Med Chem Lett 25: 1310-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.038 BindingDB Entry DOI: 10.7270/Q2057HNQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50064474 (CHEMBL3401204) Show SMILES Fc1ccc(cc1)N1CCc2nc(COc3ccccc3)c(Cl)n2C1=O Show InChI InChI=1S/C19H15ClFN3O2/c20-18-16(12-26-15-4-2-1-3-5-15)22-17-10-11-23(19(25)24(17)18)14-8-6-13(21)7-9-14/h1-9H,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assay				Bioorg Med Chem Lett 25: 1310-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.038 BindingDB Entry DOI: 10.7270/Q2057HNQ
					More data for this Ligand-Target Pair