BDBM50064638 CHEMBL3403744

SMILES: Cn1nc(cc1-c1cnc2[nH]c(cc2c1)-c1c(F)cccc1Cl)C(F)(F)F

InChI Key: InChIKey=LSFUYJPMJGSAKZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50064638   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM50064638 (CHEMBL3403744) Show SMILES Cn1nc(cc1-c1cnc2[nH]c(cc2c1)-c1c(F)cccc1Cl)C(F)(F)F Show InChI InChI=1S/C18H11ClF4N4/c1-27-14(7-15(26-27)18(21,22)23)10-5-9-6-13(25-17(9)24-8-10)16-11(19)3-2-4-12(16)20/h2-8H,1H3,(H,24,25)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of human Orai1/STIM1 expressed in HEK293 cells assessed as inhibition of channel-mediated calcium current by electrophysiology assay in pr...				Bioorg Med Chem Lett 25: 1217-22 (2015) Article DOI: 10.1016/j.bmcl.2015.01.063 BindingDB Entry DOI: 10.7270/Q2KW5HQC
					More data for this Ligand-Target Pair