BDBM50064652 (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid (4-guanidino-butyl)-amide::CHEMBL63033::D-Phe-Pro-p-Amidinobenzylamine analogue
SMILES: N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCCCCNC(N)=N
InChI Key: InChIKey=FWGBPNKASCASNV-CVEARBPZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM50064652 ((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
3-Dimensional Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of thrombin | J Med Chem 41: 2068-75 (1998) Article DOI: 10.1021/jm970796l BindingDB Entry DOI: 10.7270/Q269748G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50064652 ((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibitory activity against hydrolysis of human alpha thrombin | Bioorg Med Chem Lett 12: 45-9 (2001) BindingDB Entry DOI: 10.7270/Q2GX4C3P | |||||||||||
More data for this Ligand-Target Pair |