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BDBM50065277 5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihydro-indol-2-one::5-Chloro-3-[1-(4-morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL421548

SMILES: Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1

InChI Key: InChIKey=DVKIICSQTRTPIE-BOPFTXTBSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50065277   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50065277
PNG
(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a 4.07E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065277
PNG
(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a 4.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065277
PNG
(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM50065277
PNG
(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50065277
PNG
(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (human))
BDBM50065277
PNG
(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair