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BDBM50065283 4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester::CHEMBL316008

SMILES: CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C

InChI Key: InChIKey=FRFBYLIZAQERFO-WQLSENKSSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50065283   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a 180n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair