BDBM50065297 3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-one::3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL48760
SMILES: CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
InChI Key: InChIKey=IRQQWCZKCUQNSO-LFIBNONCSA-N
Data: 14 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Vascular endothelial growth factor receptor 2 (Mus musculus) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | J Med Chem 43: 3020-32 (2000) BindingDB Entry DOI: 10.7270/Q2HM59P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc. Curated by ChEMBL | Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor | J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Mus musculus) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc. Curated by ChEMBL | Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK). | J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc. Curated by ChEMBL | Assay Description Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK). | J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc. Curated by ChEMBL | Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK). | J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.69E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc. Curated by ChEMBL | Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK) | J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase AmpC (Escherichia coli) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibitory activity against Amp C beta-Lactamase | J Med Chem 46: 4265-72 (2003) Article DOI: 10.1021/jm030266r BindingDB Entry DOI: 10.7270/Q29C6Z59 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase AmpC (Escherichia coli) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of buffer | J Med Chem 45: 1712-22 (2002) BindingDB Entry DOI: 10.7270/Q20C4WHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Gallus gallus (Chicken)) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibitory activity against cloned Dihydrofolate reductase (cDHFR) | J Med Chem 45: 1712-22 (2002) BindingDB Entry DOI: 10.7270/Q20C4WHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase AmpC (Escherichia coli) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibitory activity against beta-lactamase in the presence of 5 mM KPi concentration of buffer | J Med Chem 45: 1712-22 (2002) BindingDB Entry DOI: 10.7270/Q20C4WHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-galactosidase (Homo sapiens (Human)) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibition of Beta-galactosidase | J Med Chem 45: 1712-22 (2002) BindingDB Entry DOI: 10.7270/Q20C4WHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase AmpC (Escherichia coli) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibitory activity against beta-lactamase | J Med Chem 45: 1712-22 (2002) BindingDB Entry DOI: 10.7270/Q20C4WHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase AmpC (Escherichia coli) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibitory activity against beta-lactamase in the presence of 50 mM KPi concentration of buffer | J Med Chem 45: 1712-22 (2002) BindingDB Entry DOI: 10.7270/Q20C4WHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Chymotrypsin (Homo sapiens (Human)) | BDBM50065297 (3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibitory activity against chymotrypsinogen | J Med Chem 45: 1712-22 (2002) BindingDB Entry DOI: 10.7270/Q20C4WHD | |||||||||||
More data for this Ligand-Target Pair |