BDBM50065307 5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)-1,3-dihydro-indol-2-one::5-Chloro-3-[1-(4-hydroxy-3,5-diisopropyl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL89723

SMILES: CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O

InChI Key: InChIKey=OHYZPHUXMLDXTQ-NVMNQCDNSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50065307   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Mus musculus)	BDBM50065307 (5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...) Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O Show InChI InChI=1S/C21H22ClNO2/c1-11(2)15-7-13(8-16(12(3)4)20(15)24)9-18-17-10-14(22)5-6-19(17)23-21(18)25/h5-12,24H,1-4H3,(H,23,25)/b18-9-	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)				J Med Chem 43: 3020-32 (2000) BindingDB Entry DOI: 10.7270/Q2HM59P2
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50065307 (5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...) Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O Show InChI InChI=1S/C21H22ClNO2/c1-11(2)15-7-13(8-16(12(3)4)20(15)24)9-18-17-10-14(22)5-6-19(17)23-21(18)25/h5-12,24H,1-4H3,(H,23,25)/b18-9-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50065307 (5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...) Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O Show InChI InChI=1S/C21H22ClNO2/c1-11(2)15-7-13(8-16(12(3)4)20(15)24)9-18-17-10-14(22)5-6-19(17)23-21(18)25/h5-12,24H,1-4H3,(H,23,25)/b18-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Mus musculus)	BDBM50065307 (5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...) Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O Show InChI InChI=1S/C21H22ClNO2/c1-11(2)15-7-13(8-16(12(3)4)20(15)24)9-18-17-10-14(22)5-6-19(17)23-21(18)25/h5-12,24H,1-4H3,(H,23,25)/b18-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50065307 (5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...) Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O Show InChI InChI=1S/C21H22ClNO2/c1-11(2)15-7-13(8-16(12(3)4)20(15)24)9-18-17-10-14(22)5-6-19(17)23-21(18)25/h5-12,24H,1-4H3,(H,23,25)/b18-9-	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50065307 (5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...) Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O Show InChI InChI=1S/C21H22ClNO2/c1-11(2)15-7-13(8-16(12(3)4)20(15)24)9-18-17-10-14(22)5-6-19(17)23-21(18)25/h5-12,24H,1-4H3,(H,23,25)/b18-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair