BDBM50065311 3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL316020

SMILES: Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C

InChI Key: InChIKey=RSEXIUPHAVGKPO-GHXNOFRVSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50065311   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50065311 (3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-yliden...) Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O/c1-9-8-16-14(10(9)2)7-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-7-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Mus musculus)	BDBM50065311 (3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-yliden...) Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O/c1-9-8-16-14(10(9)2)7-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-7-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50065311 (3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-yliden...) Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O/c1-9-8-16-14(10(9)2)7-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50065311 (3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-yliden...) Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O/c1-9-8-16-14(10(9)2)7-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-7-	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50065311 (3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-yliden...) Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O/c1-9-8-16-14(10(9)2)7-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-7-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).				J Med Chem 41: 2588-603 (1998) Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT
					More data for this Ligand-Target Pair