Found 3 hits for monomerid = 50065456 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50065456
(CHEMBL3402741)Show SMILES CCN(CC)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2ccc(OC)c(OC)c2)c1 |c:19| Show InChI InChI=1S/C26H34N4O5S/c1-5-29(6-2)13-8-14-35-25(31)27-21-10-7-9-19(15-21)17-30-26(32)36-18-22(28-30)20-11-12-23(33-3)24(16-20)34-4/h7,9-12,15-16H,5-6,8,13-14,17-18H2,1-4H3,(H,27,31) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research& Development
Curated by ChEMBL
| Assay Description Inhibition of PDE4 (unknown origin) |
Bioorg Med Chem Lett 25: 1597-602 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.002 BindingDB Entry DOI: 10.7270/Q2HX1FBT |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50065456
(CHEMBL3402741)Show SMILES CCN(CC)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2ccc(OC)c(OC)c2)c1 |c:19| Show InChI InChI=1S/C26H34N4O5S/c1-5-29(6-2)13-8-14-35-25(31)27-21-10-7-9-19(15-21)17-30-26(32)36-18-22(28-30)20-11-12-23(33-3)24(16-20)34-4/h7,9-12,15-16H,5-6,8,13-14,17-18H2,1-4H3,(H,27,31) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research& Development
Curated by ChEMBL
| Assay Description Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay |
Bioorg Med Chem Lett 25: 1597-602 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.002 BindingDB Entry DOI: 10.7270/Q2HX1FBT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50065456
(CHEMBL3402741)Show SMILES CCN(CC)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2ccc(OC)c(OC)c2)c1 |c:19| Show InChI InChI=1S/C26H34N4O5S/c1-5-29(6-2)13-8-14-35-25(31)27-21-10-7-9-19(15-21)17-30-26(32)36-18-22(28-30)20-11-12-23(33-3)24(16-20)34-4/h7,9-12,15-16H,5-6,8,13-14,17-18H2,1-4H3,(H,27,31) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research& Development
Curated by ChEMBL
| Assay Description Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay |
Bioorg Med Chem Lett 25: 1597-602 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.002 BindingDB Entry DOI: 10.7270/Q2HX1FBT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |