BindingDB PrimarySearch

BDBM50065790 (E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid::2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid::2-[(E)-2-(2,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid::2-[2-(2,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid::CHEMBL36586

SMILES: OC(=O)c1ccc2ccc(\C=C\c3ccc(O)cc3O)nc2c1O

InChI Key: InChIKey=CPDSFOPJYPRZMV-ORCRQEGFSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50065790
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Integrase (Human immunodeficiency virus 1)	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description In vitro anti-HIV integrase activity of the compound was tested against integration(strand transfer) of target plasmid.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description HIV integrase inhibitory potency of the compound was evaluated as IC50 on 3' processing of target DNA.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description Inhibitory activity against Integrase in strand transfer(integration)				J Med Chem 43: 1533-40 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PNQ
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jadavpur University Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase 3' processing activity				Eur J Med Chem 43: 81-92 (2008) Article DOI: 10.1016/j.ejmech.2007.02.021 BindingDB Entry DOI: 10.7270/Q24170XZ
Jadavpur University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Paris Sud Curated by ChEMBL					Assay Description Inhibition of PIM1				Bioorg Med Chem Lett 20: 2801-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.061 BindingDB Entry DOI: 10.7270/Q2125STS
Universit£ Paris Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UMR 8532 Curated by ChEMBL					Assay Description Inhibition of human immunodeficiency virus-1 (HIV-1) integrase.				J Med Chem 43: 1949-57 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2RB759N
CNRS UMR 8532 Curated by ChEMBL					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Rous sarcoma virus (strain Prague C) (RSV-PrC))	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.83E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UMR 8532 Curated by ChEMBL					Assay Description Inhibition of rous sarcoma virus (RSV) Integrase.				J Med Chem 43: 1949-57 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2RB759N
CNRS UMR 8532 Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065790 ((E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description Inhibitory activity against Integrase in 3'-end- processing				J Med Chem 43: 1533-40 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PNQ
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair