BDBM50065798 Acetic acid 2-((E)-styryl)-quinolin-8-yl ester::Acetic acid 2-styryl-quinolin-8-yl ester::CHEMBL293788

SMILES: CC(=O)Oc1cccc2ccc(\C=C\c3ccccc3)nc12

InChI Key: InChIKey=OSAOSEQEULTDNB-ZRDIBKRKSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50065798   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065798 (Acetic acid 2-((E)-styryl)-quinolin-8-yl ester | A...) Show SMILES CC(=O)Oc1cccc2ccc(\C=C\c3ccccc3)nc12 Show InChI InChI=1S/C19H15NO2/c1-14(21)22-18-9-5-8-16-11-13-17(20-19(16)18)12-10-15-6-3-2-4-7-15/h2-13H,1H3/b12-10+	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description In vitro anti-HIV integrase activity of the compound was tested against integration(strand transfer) of target plasmid.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065798 (Acetic acid 2-((E)-styryl)-quinolin-8-yl ester | A...) Show SMILES CC(=O)Oc1cccc2ccc(\C=C\c3ccccc3)nc12 Show InChI InChI=1S/C19H15NO2/c1-14(21)22-18-9-5-8-16-11-13-17(20-19(16)18)12-10-15-6-3-2-4-7-15/h2-13H,1H3/b12-10+	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description HIV integrase inhibitory potency of the compound was evaluated as IC50 on 3' processing of target DNA.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065798 (Acetic acid 2-((E)-styryl)-quinolin-8-yl ester | A...) Show SMILES CC(=O)Oc1cccc2ccc(\C=C\c3ccccc3)nc12 Show InChI InChI=1S/C19H15NO2/c1-14(21)22-18-9-5-8-16-11-13-17(20-19(16)18)12-10-15-6-3-2-4-7-15/h2-13H,1H3/b12-10+	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jadavpur University Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase 3' processing activity				Eur J Med Chem 43: 81-92 (2008) Article DOI: 10.1016/j.ejmech.2007.02.021 BindingDB Entry DOI: 10.7270/Q24170XZ
					More data for this Ligand-Target Pair
Rous sarcoma virus integrase (Rous sarcoma virus (strain Prague C) (RSV-PrC))	BDBM50065798 (Acetic acid 2-((E)-styryl)-quinolin-8-yl ester | A...) Show SMILES CC(=O)Oc1cccc2ccc(\C=C\c3ccccc3)nc12 Show InChI InChI=1S/C19H15NO2/c1-14(21)22-18-9-5-8-16-11-13-17(20-19(16)18)12-10-15-6-3-2-4-7-15/h2-13H,1H3/b12-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UMR 8532 Curated by ChEMBL					Assay Description Inhibition of rous sarcoma virus (RSV) Integrase.				J Med Chem 43: 1949-57 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2RB759N
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065798 (Acetic acid 2-((E)-styryl)-quinolin-8-yl ester | A...) Show SMILES CC(=O)Oc1cccc2ccc(\C=C\c3ccccc3)nc12 Show InChI InChI=1S/C19H15NO2/c1-14(21)22-18-9-5-8-16-11-13-17(20-19(16)18)12-10-15-6-3-2-4-7-15/h2-13H,1H3/b12-10+	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UMR 8532 Curated by ChEMBL					Assay Description Inhibition of human immunodeficiency virus-1 (HIV-1) integrase.				J Med Chem 43: 1949-57 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2RB759N
					More data for this Ligand-Target Pair