BDBM50065953 (S)-5-chloro-N-(1-(4-hydroxypiperidin-1-yl)-1-oxo-3-phenylpropan-2-yl)-1H-indole-2-carboxamide::5-Chloro-1H-indole-2-carboxylic acid [(S)-1-benzyl-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-amide::CHEMBL317410
SMILES: OC1CCN(CC1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
InChI Key: InChIKey=GNALBMXZWTYWAG-NRFANRHFSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sterol 14α-demethylase (CYP51) (Homo sapiens (Human)) | BDBM50065953 ((S)-5-chloro-N-(1-(4-hydroxypiperidin-1-yl)-1-oxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ACT LLC Curated by ChEMBL | Assay Description Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay | Drug Metab Dispos 35: 493-500 (2007) Article DOI: 10.1124/dmd.106.013888 BindingDB Entry DOI: 10.7270/Q2DF6S2H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen Phosphorylase (PYGL) (Homo sapiens (Human)) | BDBM50065953 ((S)-5-chloro-N-(1-(4-hydroxypiperidin-1-yl)-1-oxo-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat... | J Med Chem 41: 2934-8 (1998) Article DOI: 10.1021/jm980264k BindingDB Entry DOI: 10.7270/Q2NS0T1T | |||||||||||
More data for this Ligand-Target Pair |