BindingDB PrimarySearch

BDBM50066436 2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-dione::2-(2,6-dimethylphenyl)-5-hydroxyisoindoline-1,3-dione::CHEMBL424612

SMILES: Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O

InChI Key: InChIKey=GPUARNPEQNPVEX-UHFFFAOYSA-N

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50066436
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50066436 (2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-di...) Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Homo sapiens (Human))	BDBM50066436 (2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-di...) Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50066436 (2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-di...) Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.				J Med Chem 41: 263-5 (1998) Article DOI: 10.1021/jm970624o BindingDB Entry DOI: 10.7270/Q24X5BJC
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50066436 (2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-di...) Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50066436 (2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-di...) Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)				J Med Chem 41: 263-5 (1998) Article DOI: 10.1021/jm970624o BindingDB Entry DOI: 10.7270/Q24X5BJC
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50066436 (2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-di...) Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair