BDBM50066528 6-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2-dihydro-quinoline::6-(3-fluorophenyl)-2,2,4-trimethyl-1,2-dihydroquinoline::CHEMBL117585
SMILES: CC1=CC(C)(C)Nc2ccc(cc12)-c1cccc(F)c1
InChI Key: InChIKey=CHYOXMTWROVBDX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Progesterone receptor (Homo sapiens (Human)) | BDBM50066528 (6-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2-dihydro-qu...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Binding affinity against Baculovirus-Expressed hPR-A | J Med Chem 41: 3461-6 (1998) Article DOI: 10.1021/jm9801915 BindingDB Entry DOI: 10.7270/Q2KD1ZKM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50066528 (6-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2-dihydro-qu...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Scientific Computing Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]progesterone from Progesterone receptor | J Med Chem 49: 4261-8 (2006) Article DOI: 10.1021/jm060234e BindingDB Entry DOI: 10.7270/Q2V69NB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50066528 (6-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2-dihydro-qu...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Inc. Curated by ChEMBL | Assay Description In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cells | J Med Chem 41: 3461-6 (1998) Article DOI: 10.1021/jm9801915 BindingDB Entry DOI: 10.7270/Q2KD1ZKM | |||||||||||
More data for this Ligand-Target Pair |