BDBM50066981 2,3-Dihydroxy-4-isopropyl-6,7-dimethyl-naphthalene-1-carboxylic acid::CHEMBL127326
SMILES: CC(C)c1c(O)c(O)c(C(O)=O)c2cc(C)c(C)cc12
InChI Key: InChIKey=MRQUPZXQXMODNB-UHFFFAOYSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lactate dehydrogenase A (LDHA) (Homo sapiens (Human)) | BDBM50066981 (2,3-Dihydroxy-4-isopropyl-6,7-dimethyl-naphthalene...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New Mexico School of Medicine Curated by ChEMBL | Assay Description inhibitory activity against P. falciparum lactate dehydrogenase (pLDH) | J Med Chem 41: 3879-87 (1998) Article DOI: 10.1021/jm980334n BindingDB Entry DOI: 10.7270/Q298864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactate dehydrogenase B (LDHB) (Homo sapiens (Human)) | BDBM50066981 (2,3-Dihydroxy-4-isopropyl-6,7-dimethyl-naphthalene...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New Mexico School of Medicine Curated by ChEMBL | Assay Description inhibitory activity against Human Lactate Dehydrogenase (LDH-M) | J Med Chem 41: 3879-87 (1998) Article DOI: 10.1021/jm980334n BindingDB Entry DOI: 10.7270/Q298864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Homo sapiens (Human)) | BDBM50066981 (2,3-Dihydroxy-4-isopropyl-6,7-dimethyl-naphthalene...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-CRO Curated by ChEMBL | Assay Description Competitive inhibition of human LDH5 in presence of NADH | J Med Chem 59: 487-96 (2016) BindingDB Entry DOI: 10.7270/Q2B27X41 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactate dehydrogenase B (LDHB) (Homo sapiens (Human)) | BDBM50066981 (2,3-Dihydroxy-4-isopropyl-6,7-dimethyl-naphthalene...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 7.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-CRO Curated by ChEMBL | Assay Description Competitive inhibition of human LDH1 in presence of NADH | J Med Chem 59: 487-96 (2016) BindingDB Entry DOI: 10.7270/Q2B27X41 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactate dehydrogenase B (LDHB) (Homo sapiens (Human)) | BDBM50066981 (2,3-Dihydroxy-4-isopropyl-6,7-dimethyl-naphthalene...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 7.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New Mexico School of Medicine Curated by ChEMBL | Assay Description inhibitory activity against Human Lactate Dehydrogenase (LDH-H) | J Med Chem 41: 3879-87 (1998) Article DOI: 10.1021/jm980334n BindingDB Entry DOI: 10.7270/Q298864G | |||||||||||
More data for this Ligand-Target Pair |