BDBM50067305 (E)-N-({[2,4-Dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-3-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acrylamide; hydrochloride::CHEMBL552543

SMILES: CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)N1CCCC1=O)c1ccc(C)c(COc2cccc3ccc(C)nc23)c1C

InChI Key: InChIKey=FIEQAXDVHHHMAH-XMHGGMMESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50067305   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BDKRB2 (Homo sapiens (Human))	BDBM50067305 ((E)-N-({[2,4-Dimethyl-3-(2-methyl-quinolin-8-yloxy...) Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)N1CCCC1=O)c1ccc(C)c(COc2cccc3ccc(C)nc23)c1C Show InChI InChI=1S/C35H36N4O4/c1-23-10-18-30(25(3)29(23)22-43-31-8-5-7-27-15-11-24(2)37-35(27)31)38(4)34(42)21-36-32(40)19-14-26-12-16-28(17-13-26)39-20-6-9-33(39)41/h5,7-8,10-19H,6,9,20-22H2,1-4H3,(H,36,40)/b19-14+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 which was expressed in CHO (Chinese hamster ovary) cells by 50%.				J Med Chem 41: 4062-79 (1998) Article DOI: 10.1021/jm980300f BindingDB Entry DOI: 10.7270/Q2RX9CS1
					More data for this Ligand-Target Pair
Bradykinin B2 receptor (Cavia porcellus)	BDBM50067305 ((E)-N-({[2,4-Dimethyl-3-(2-methyl-quinolin-8-yloxy...) Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)N1CCCC1=O)c1ccc(C)c(COc2cccc3ccc(C)nc23)c1C Show InChI InChI=1S/C35H36N4O4/c1-23-10-18-30(25(3)29(23)22-43-31-8-5-7-27-15-11-24(2)37-35(27)31)38(4)34(42)21-36-32(40)19-14-26-12-16-28(17-13-26)39-20-6-9-33(39)41/h5,7-8,10-19H,6,9,20-22H2,1-4H3,(H,36,40)/b19-14+	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.				J Med Chem 41: 4062-79 (1998) Article DOI: 10.1021/jm980300f BindingDB Entry DOI: 10.7270/Q2RX9CS1
					More data for this Ligand-Target Pair