BDBM50067563 (S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid::2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid::CHEMBL274122
SMILES: CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(O)=O
InChI Key: InChIKey=OKLOPBKXGZVBCB-QHCPKHFHSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50067563 ((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase) | Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50067563 ((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against farnesyltransferase (FT) using SPA assay | Bioorg Med Chem Lett 9: 703-8 (1999) BindingDB Entry DOI: 10.7270/Q2G73CWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50067563 ((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of human recombinant FTase using [3H]farnesyldiphosphate | Medchemcomm 4: 476-492 (2013) Article DOI: 10.1039/c2md20299a BindingDB Entry DOI: 10.7270/Q2HD7ZN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Saccharomyces cerevisiae (Baker's yeast)) | BDBM50067563 ((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...) | KEGG GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps-Universität Marburg Curated by ChEMBL | Assay Description Inhibitory activity against yeast farnesyltransferase | J Med Chem 44: 3117-24 (2001) BindingDB Entry DOI: 10.7270/Q2VH5N43 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Bos taurus (bovine)) | BDBM50067563 ((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...) | PDB MMDB KEGG B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro inhibition of farnesyltransferase from bovine brain | J Med Chem 41: 4288-300 (1998) Article DOI: 10.1021/jm980298s BindingDB Entry DOI: 10.7270/Q20G3KTC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Bos taurus (bovine)) | BDBM50067563 ((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...) | PDB MMDB KEGG B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay | J Med Chem 42: 3701-10 (1999) Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC | |||||||||||
More data for this Ligand-Target Pair |