BDBM50067865 CHEMBL337603::N*6*-(3,4-Dimethoxy-phenyl)-N*6*-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

SMILES: COc1ccc(cc1OC)N(C)c1ccc2nc(N)nc(N)c2n1

InChI Key: InChIKey=NEYWXHQYBGGVGI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50067865   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50067865 (CHEMBL337603 | N*6*-(3,4-Dimethoxy-phenyl)-N*6*-me...) Show SMILES COc1ccc(cc1OC)N(C)c1ccc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C16H18N6O2/c1-22(9-4-6-11(23-2)12(8-9)24-3)13-7-5-10-14(20-13)15(17)21-16(18)19-10/h4-8H,1-3H3,(H4,17,18,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver				J Med Chem 41: 4533-41 (1998) Article DOI: 10.1021/jm980206z BindingDB Entry DOI: 10.7270/Q2FX78KJ
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50067865 (CHEMBL337603 | N*6*-(3,4-Dimethoxy-phenyl)-N*6*-me...) Show SMILES COc1ccc(cc1OC)N(C)c1ccc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C16H18N6O2/c1-22(9-4-6-11(23-2)12(8-9)24-3)13-7-5-10-14(20-13)15(17)21-16(18)19-10/h4-8H,1-3H3,(H4,17,18,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondii				J Med Chem 41: 4533-41 (1998) Article DOI: 10.1021/jm980206z BindingDB Entry DOI: 10.7270/Q2FX78KJ
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50067865 (CHEMBL337603 | N*6*-(3,4-Dimethoxy-phenyl)-N*6*-me...) Show SMILES COc1ccc(cc1OC)N(C)c1ccc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C16H18N6O2/c1-22(9-4-6-11(23-2)12(8-9)24-3)13-7-5-10-14(20-13)15(17)21-16(18)19-10/h4-8H,1-3H3,(H4,17,18,19,21)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis carinii				J Med Chem 41: 4533-41 (1998) Article DOI: 10.1021/jm980206z BindingDB Entry DOI: 10.7270/Q2FX78KJ
					More data for this Ligand-Target Pair