BDBM50068224 (E)-1,3-Bis-(4-hydroxy-phenyl)-propenone::1,3-bis(4-hydroxyphenyl)prop-2-en-1-one::4',4-Dihydroxychalcone::4,4'-dihydroxychalcone::CHEMBL145927

SMILES: Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1

InChI Key: InChIKey=FZQLEXXZAVVCCA-XCVCLJGOSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50068224   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50068224 ((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1 Show InChI InChI=1S/C15H12O3/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,16-17H/b10-3+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Department of Functional Crop Curated by ChEMBL					Assay Description Competitive inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot analysis				Eur J Med Chem 45: 2010-7 (2010) Article DOI: 10.1016/j.ejmech.2010.01.049 BindingDB Entry DOI: 10.7270/Q2H70FZM
					More data for this Ligand-Target Pair
Coagulation factor VII/tissue factor (Homo sapiens (Human))	BDBM50068224 ((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1 Show InChI InChI=1S/C15H12O3/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,16-17H/b10-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...				Citation and Details Article DOI: 10.1007/s00044-012-0330-5 BindingDB Entry DOI: 10.7270/Q23F4SJ7
					More data for this Ligand-Target Pair
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM50068224 ((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1 Show InChI InChI=1S/C15H12O3/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,16-17H/b10-3+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.17E+5	n/a	n/a	n/a	n/a	n/a	n/a
Guangxi Medical University Curated by ChEMBL					Assay Description Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...				Bioorg Med Chem Lett 27: 3602-3606 (2017) Article DOI: 10.1016/j.bmcl.2017.01.053 BindingDB Entry DOI: 10.7270/Q2F76G1K
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50068224 ((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1 Show InChI InChI=1S/C15H12O3/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,16-17H/b10-3+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Department of Functional Crop Curated by ChEMBL					Assay Description Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by spectrophotometric analysis				Eur J Med Chem 45: 2010-7 (2010) Article DOI: 10.1016/j.ejmech.2010.01.049 BindingDB Entry DOI: 10.7270/Q2H70FZM
					More data for this Ligand-Target Pair