Found 4 hits for monomerid = 50068286 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphodiesterase 7
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031 BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of PDE5A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031 BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3 (PDE3)
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of PDE3A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031 BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031 BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this Ligand-Target Pair | |