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BDBM50068357 CHEMBL3402343

SMILES: CCC(=O)N1N=C(SC11CCOc2ccccc12)c1cc(F)ccc1F

InChI Key: InChIKey=MDDQGDJGSXWQBN-UHFFFAOYNA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50068357   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50068357
PNG
(CHEMBL3402343)
Show SMILES CCC(=O)N1N=C(SC11CCOc2ccccc12)c1cc(F)ccc1F |c:5|
Show InChI InChI=1/C19H16F2N2O2S/c1-2-17(24)23-19(9-10-25-16-6-4-3-5-14(16)19)26-18(22-23)13-11-12(20)7-8-15(13)21/h3-8,11H,2,9-10H2,1H3
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MMDB

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Article
PubMed
n/an/an/an/a 452n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KSP in human HCT116 cells assessed as phos-histone H3 level by immunofluorescent assay


Bioorg Med Chem 23: 2424-34 (2015)


Article DOI: 10.1016/j.bmc.2015.03.052
More data for this
Ligand-Target Pair