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BDBM50068381 CHEMBL3402337

SMILES: CC(=O)N1N=C(SC11CCOc2ccccc12)c1cc(F)ccc1F

InChI Key: InChIKey=SIFDIWHUFOMQGF-UHFFFAOYNA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50068381   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50068381
PNG
(CHEMBL3402337)
Show SMILES CC(=O)N1N=C(SC11CCOc2ccccc12)c1cc(F)ccc1F |c:4|
Show InChI InChI=1/C18H14F2N2O2S/c1-11(23)22-18(8-9-24-16-5-3-2-4-14(16)18)25-17(21-22)13-10-12(19)6-7-15(13)20/h2-7,10H,8-9H2,1H3
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MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 139n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KSP in human HCT116 cells assessed as phos-histone H3 level by immunofluorescent assay


Bioorg Med Chem 23: 2424-34 (2015)


Article DOI: 10.1016/j.bmc.2015.03.052
More data for this
Ligand-Target Pair