BDBM50068471 (2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane
SMILES: CN1C2CCC1[C@H](C(C2)c1ccc(C)cc1)c1ccccc1
InChI Key: InChIKey=YJWQTICONBXOHT-FNNAPWSISA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Binding affinity of compound on dopamine transporters of rat striated membranes using [3H]- mazindol. | J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Binding affinity for [3H]DA (Dopamine transporter) uptake by striated synaptosomes | J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine uptake at striatal nerve endings by dopamine transporter | Bioorg Med Chem Lett 9: 3325-8 (2000) BindingDB Entry DOI: 10.7270/Q2RB754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]mazindol from cocaine binding site on Dopamine transporter (DAT) | Bioorg Med Chem Lett 9: 3325-8 (2000) BindingDB Entry DOI: 10.7270/Q2RB754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Binding affinity for Serotonin transporter was determined by [3H]5-HT (serotonin) uptake by striated synaptosomes | J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Inhibition of [3H]5-HT uptake at striatal nerve endings by serotonin transporter | Bioorg Med Chem Lett 9: 3325-8 (2000) BindingDB Entry DOI: 10.7270/Q2RB754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Inhibitory activity determined for [3H]DA (Dopamine transporter) uptake by striated synaptosomes | J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Inhibitory activity on dopamine transporters of rat striated membranes using [3H]- mazindol. | J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50068471 ((2R,8S)-8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Inhibitory activity against Serotonin transporter was determined for [3H]5-HT (serotonin) uptake by striated synaptosomes | J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7 | |||||||||||
More data for this Ligand-Target Pair |