BDBM50069096 CHEMBL3403517::US10189853, Compound 10

SMILES: COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12

InChI Key: InChIKey=OYHXDIYGCSLVFT-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50069096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50069096 (CHEMBL3403517 | US10189853, Compound 10) Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12 Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of EGFR in human A431 cells compound pretreated for 60 min before EGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot method				Bioorg Med Chem 23: 2408-23 (2015) Article DOI: 10.1016/j.bmc.2015.03.061 BindingDB Entry DOI: 10.7270/Q2765H1D
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50069096 (CHEMBL3403517 | US10189853, Compound 10) Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12 Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot method				Bioorg Med Chem 23: 2408-23 (2015) Article DOI: 10.1016/j.bmc.2015.03.061 BindingDB Entry DOI: 10.7270/Q2765H1D
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50069096 (CHEMBL3403517 | US10189853, Compound 10) Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12 Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of PDGFR-beta in human U251 cells compound pretreated for 60 min before PDGF-BB stimulation for 10 mins by phosphotyrosine ELISA cytoblot ...				Bioorg Med Chem 23: 2408-23 (2015) Article DOI: 10.1016/j.bmc.2015.03.061 BindingDB Entry DOI: 10.7270/Q2765H1D
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50069096 (CHEMBL3403517 | US10189853, Compound 10) Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12 Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	58.2	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University of the Holy Spirit US Patent					Assay Description RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...				US Patent US10189853 (2019) BindingDB Entry DOI: 10.7270/Q2RX9F5S
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50069096 (CHEMBL3403517 | US10189853, Compound 10) Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12 Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University of the Holy Spirit US Patent					Assay Description RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...				US Patent US10189853 (2019) BindingDB Entry DOI: 10.7270/Q2RX9F5S
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50069096 (CHEMBL3403517 | US10189853, Compound 10) Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12 Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.2	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University of the Holy Spirit US Patent					Assay Description RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...				US Patent US10189853 (2019) BindingDB Entry DOI: 10.7270/Q2RX9F5S
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50069096 (CHEMBL3403517 | US10189853, Compound 10) Show SMILES COc1ccc2N(CCCc2c1)c1nc(C)nc2oc(C)cc12 Show InChI InChI=1S/C18H19N3O2/c1-11-9-15-17(19-12(2)20-18(15)23-11)21-8-4-5-13-10-14(22-3)6-7-16(13)21/h6-7,9-10H,4-5,8H2,1-3H3	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of bovine brain tubulin assembly				Bioorg Med Chem 23: 2408-23 (2015) Article DOI: 10.1016/j.bmc.2015.03.061 BindingDB Entry DOI: 10.7270/Q2765H1D
					More data for this Ligand-Target Pair