BDBM50069801 CHEMBL3407580

SMILES: CC(C)C[C@]1(N=CN(CC2CC2)[C@H]1c1ccc(Cl)cc1)C(=O)NCCc1ccncc1

InChI Key: InChIKey=FLEPRYJBTOPZTM-UKILVPOCSA-N

Data: 1 Kd

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50069801   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50069801 (CHEMBL3407580) Show SMILES CC(C)C[C@]1(N=CN(CC2CC2)[C@H]1c1ccc(Cl)cc1)C(=O)NCCc1ccncc1 |r,c:5| Show InChI InChI=1S/C25H31ClN4O/c1-18(2)15-25(24(31)28-14-11-19-9-12-27-13-10-19)23(21-5-7-22(26)8-6-21)30(17-29-25)16-20-3-4-20/h5-10,12-13,17-18,20,23H,3-4,11,14-16H2,1-2H3,(H,28,31)/t23-,25+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human MDM2 by fluorescence polarization assay				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair