BDBM50070114 (+/-)-thalidomide::2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione::2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione::CHEMBL468::K-17::THALIDOMIDE::Thalomid::[(R,S)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
SMILES: O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
InChI Key: InChIKey=UEJJHQNACJXSKW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cereblon isoform 4 (Magnetospirillum gryphiswaldense) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute for Developmental Biology Curated by ChEMBL | Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysis | J Med Chem 59: 770-4 (2016) BindingDB Entry DOI: 10.7270/Q2PR7XVF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cereblon isoform 4 (Magnetospirillum gryphiswaldense) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute for Developmental Biology Curated by ChEMBL | Assay Description Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assay | J Med Chem 62: 6615-6629 (2019) Article DOI: 10.1021/acs.jmedchem.9b00454 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein cereblon (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 2.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute for Developmental Biology Curated by ChEMBL | Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis | J Med Chem 59: 770-4 (2016) BindingDB Entry DOI: 10.7270/Q2PR7XVF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hIL-1beta (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Granulocyte-macrophage colony-stimulating factor (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mediator of DNA damage checkpoint protein 1 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C motif chemokine 3 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C motif chemokine 4 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tumor necrosis factor (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Inhibitory activity (RA1) of the compound against Prostaglandin G/H synthase 1 was calculated relative to aspirin | Bioorg Med Chem Lett 12: 1043-6 (2002) BindingDB Entry DOI: 10.7270/Q28K78D9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase (Cyclooxygenase-2) (Ovis aries (Sheep)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Inhibitory activity (RA2) of the compound against Prostaglandin G/H synthase 2 was calculated relative to aspirin | Bioorg Med Chem Lett 12: 1043-6 (2002) BindingDB Entry DOI: 10.7270/Q28K78D9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon isoform 4 (Magnetospirillum gryphiswaldense) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute for Developmental Biology Curated by ChEMBL | Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay | J Med Chem 59: 770-4 (2016) BindingDB Entry DOI: 10.7270/Q2PR7XVF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein cereblon (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 2.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute for Developmental Biology Curated by ChEMBL | Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay | J Med Chem 59: 770-4 (2016) BindingDB Entry DOI: 10.7270/Q2PR7XVF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation Curated by ChEMBL | Assay Description Inhibition of PDE4 enzyme from U937 cells | Bioorg Med Chem Lett 8: 2669-74 (1998) BindingDB Entry DOI: 10.7270/Q2BK1FJH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... | Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CRBN-DDB1 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB | n/a | n/a | 301 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glyceraldehyde-3-phosphate dehydrogenase cytosolic (Leishmania mexicana) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CRBN-DDB1 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB | n/a | n/a | 268 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DNA damage-binding protein 1 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 70 |
Celgene | Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S... | Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Interleukin-6 (Homo sapiens (Human)) | BDBM50070114 ((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair |