BDBM50070192 (6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (6-chloro-pyridazin-3-yl)-amide::CHEMBL14089

SMILES: CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1

InChI Key: InChIKey=CQMXKYDRFMRPTO-QGPMSJSTSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50070192   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (RAT)	BDBM50070192 ((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...) Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1 Show InChI InChI=1S/C24H28ClN5O/c1-24(2,3)17-6-5-15-16-9-14(23(31)27-20-8-7-19(25)28-29-20)12-30(4)18(16)10-13-11-26-22(17)21(13)15/h5-8,11,14,16,18,26H,9-10,12H2,1-4H3,(H,27,29,31)/t14-,16-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL					Assay Description Displacement of [3H]-SCH-23,390 from D1 receptor in rat striatum				Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50070192 ((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...) Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1 Show InChI InChI=1S/C24H28ClN5O/c1-24(2,3)17-6-5-15-16-9-14(23(31)27-20-8-7-19(25)28-29-20)12-30(4)18(16)10-13-11-26-22(17)21(13)15/h5-8,11,14,16,18,26H,9-10,12H2,1-4H3,(H,27,29,31)/t14-,16-,18-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL					Assay Description Displacement of [3H]-spiroperidol from D2 receptor in rat striatum				Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3
					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50070192 ((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...) Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1 Show InChI InChI=1S/C24H28ClN5O/c1-24(2,3)17-6-5-15-16-9-14(23(31)27-20-8-7-19(25)28-29-20)12-30(4)18(16)10-13-11-26-22(17)21(13)15/h5-8,11,14,16,18,26H,9-10,12H2,1-4H3,(H,27,29,31)/t14-,16-,18-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL					Assay Description Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in rat frontal cortex				Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50070192 ((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...) Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1 Show InChI InChI=1S/C24H28ClN5O/c1-24(2,3)17-6-5-15-16-9-14(23(31)27-20-8-7-19(25)28-29-20)12-30(4)18(16)10-13-11-26-22(17)21(13)15/h5-8,11,14,16,18,26H,9-10,12H2,1-4H3,(H,27,29,31)/t14-,16-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat pre frontal cortex				Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3
					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50070192 ((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...) Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1 Show InChI InChI=1S/C24H28ClN5O/c1-24(2,3)17-6-5-15-16-9-14(23(31)27-20-8-7-19(25)28-29-20)12-30(4)18(16)10-13-11-26-22(17)21(13)15/h5-8,11,14,16,18,26H,9-10,12H2,1-4H3,(H,27,29,31)/t14-,16-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL					Assay Description Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortex				Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50070192 ((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...) Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1 Show InChI InChI=1S/C24H28ClN5O/c1-24(2,3)17-6-5-15-16-9-14(23(31)27-20-8-7-19(25)28-29-20)12-30(4)18(16)10-13-11-26-22(17)21(13)15/h5-8,11,14,16,18,26H,9-10,12H2,1-4H3,(H,27,29,31)/t14-,16-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampus				Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3
					More data for this Ligand-Target Pair