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BDBM50070209 Aciphex::CHEBI:8768::LY-307640::RABEPRAZOLE::Rabeprazole

SMILES: COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C

InChI Key:

Data: 1 KI 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50070209
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM50070209 (Aciphex \| CHEBI:8768 \| LY-307640 \| RABEPRAZOLE \| R...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...				J Med Chem 58: 778-84 (2015) Article DOI: 10.1021/jm501543u BindingDB Entry DOI: 10.7270/Q20K2B7H
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Dimethylarginine dimethylaminohydrolase 1 (DDAH) (Homo sapiens (Human))	BDBM50070209 (Aciphex \| CHEBI:8768 \| LY-307640 \| RABEPRAZOLE \| R...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Lille Curated by ChEMBL					Assay Description Inhibition of human recombinant DDAH1 reduction in L-citrulline formation using ADMA as substrate				Eur J Med Chem 179: 557-566 (2019) Article DOI: 10.1016/j.ejmech.2019.06.057
Univ. Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50070209 (Aciphex \| CHEBI:8768 \| LY-307640 \| RABEPRAZOLE \| R...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Wroc?aw University of Technology Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease assessed as amount of ammonia after 15 mins by indophenol method				J Med Chem 59: 8125-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00986
Wroc?aw University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor (Homo sapiens (Human))	BDBM50070209 (Aciphex \| CHEBI:8768 \| LY-307640 \| RABEPRAZOLE \| R...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Lille Curated by ChEMBL					Assay Description Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...				Eur J Med Chem 179: 557-566 (2019) Article DOI: 10.1016/j.ejmech.2019.06.057
Univ. Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50070209 (Aciphex \| CHEBI:8768 \| LY-307640 \| RABEPRAZOLE \| R...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...				J Med Chem 58: 778-84 (2015) Article DOI: 10.1021/jm501543u BindingDB Entry DOI: 10.7270/Q20K2B7H
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase (Homo sapiens (Human))	BDBM50070209 (Aciphex \| CHEBI:8768 \| LY-307640 \| RABEPRAZOLE \| R...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...				Bioorg Med Chem Lett 27: 2962-2966 (2017) Article DOI: 10.1016/j.bmcl.2017.05.010 BindingDB Entry DOI: 10.7270/Q2W66P5J
					More data for this Ligand-Target Pair