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BDBM50070293 2-({[3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester::CHEMBL429390

SMILES: Cc1cn(C2CC(O[Si](C)(C)C(C)(C)C)C(CNC(=O)CC3(C)CC(CN3C(=O)OC(C)(C)C)O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)O2)c(=O)[nH]c1=O

InChI Key: InChIKey=XKPREZASYVOYQM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50070293   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50070293
PNG
(2-({[3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methy...)
Show SMILES Cc1cn(C2CC(O[Si](C)(C)C(C)(C)C)C(CNC(=O)CC3(C)CC(CN3C(=O)OC(C)(C)C)O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C44H66N4O8Si2/c1-30-28-47(39(51)46-38(30)50)37-24-34(56-57(12,13)42(5,6)7)35(53-37)27-45-36(49)26-44(11)25-31(29-48(44)40(52)54-41(2,3)4)55-58(43(8,9)10,32-20-16-14-17-21-32)33-22-18-15-19-23-33/h14-23,28,31,34-35,37H,24-27,29H2,1-13H3,(H,45,49)(H,46,50,51)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



University of Wales Cardiff

Curated by ChEMBL


Assay Description
Concentration required for no significant inhibitory activity against HIV-1 reverse transcriptase


Bioorg Med Chem Lett 8: 1211-4 (1999)


BindingDB Entry DOI: 10.7270/Q2PZ580P
More data for this
Ligand-Target Pair