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BDBM50070295 4-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-2-({[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl]-carbamoyl}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester::CHEMBL19871

SMILES: Cc1cn(C2OC(CNC(=O)CC3(C)CC(CN3C(=O)OC(C)(C)C)O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C=C2)c(=O)[nH]c1=O

InChI Key: InChIKey=ZMBRGGTYWZWNBP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50070295   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50070295
PNG
(4-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-2-({[5...)
Show SMILES Cc1cn(C2OC(CNC(=O)CC3(C)CC(CN3C(=O)OC(C)(C)C)O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C=C2)c(=O)[nH]c1=O |c:46|
Show InChI InChI=1S/C38H50N4O7Si/c1-26-24-41(34(45)40-33(26)44)32-20-19-27(47-32)23-39-31(43)22-38(8)21-28(25-42(38)35(46)48-36(2,3)4)49-50(37(5,6)7,29-15-11-9-12-16-29)30-17-13-10-14-18-30/h9-20,24,27-28,32H,21-23,25H2,1-8H3,(H,39,43)(H,40,44,45)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



University of Wales Cardiff

Curated by ChEMBL


Assay Description
Concentration required for no significant inhibitory activity against HIV-1 reverse transcriptase


Bioorg Med Chem Lett 8: 1211-4 (1999)


BindingDB Entry DOI: 10.7270/Q2PZ580P
More data for this
Ligand-Target Pair