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SMILES: CCc1cnc(nc1)-n1nc(OC(C)C)c(Oc2c(F)cccc2F)c1C

InChI Key: InChIKey=SONXINISKZIKPN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50070908   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM50070908
PNG
(CHEMBL3409491)
Show SMILES CCc1cnc(nc1)-n1nc(OC(C)C)c(Oc2c(F)cccc2F)c1C
Show InChI InChI=1S/C19H20F2N4O2/c1-5-13-9-22-19(23-10-13)25-12(4)16(18(24-25)26-11(2)3)27-17-14(20)7-6-8-15(17)21/h6-11H,5H2,1-4H3
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PubMed
n/an/a 0.794n/an/an/an/an/an/a



Institut Pasteur

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometry

J Med Chem 58: 860-77 (2015)


Article DOI: 10.1021/jm501446r
BindingDB Entry DOI: 10.7270/Q2K9396J
More data for this
Ligand-Target Pair