BDBM50071161 (2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid::4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid(1-benzyl-APDC)::CHEMBL60238

SMILES: N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O

InChI Key: InChIKey=LYCSUAGKQMUTBR-ZWNOBZJWSA-N

Data: 4 KI  12 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50071161   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Antagonist potency against cloned Metabotropic glutamate receptor 2				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned metabotropic glutamate receptor 5				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 1				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 5				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6) (Rattus norvegicus (Rat))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 6				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
					More data for this Ligand-Target Pair
GRM8 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 2				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.21E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50071161 ((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...) Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair