BDBM50071695 (S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-3-phenylmethanesulfonylamino-piperidine-3-carboxylic acid ethyl ester::CHEMBL85282
SMILES: CCOC(=O)[C@@]1(CCCN(CC(=O)N[C@H]2CCCN([C@@H]2O)C(N)=N)C1=O)NS(=O)(=O)Cc1ccccc1
InChI Key: InChIKey=YLPFNSPUPARBLY-GWJPWWOOSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor X (Homo sapiens (Human)) | BDBM50071695 ((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity was evaluated against thrombin factor Xa (FXa) | Bioorg Med Chem Lett 8: 2501-6 (1999) BindingDB Entry DOI: 10.7270/Q28C9VCK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (Homo sapiens (Human)) | BDBM50071695 ((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 271 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity was evaluated against thrombolytic enzyme plasmin | Bioorg Med Chem Lett 8: 2501-6 (1999) BindingDB Entry DOI: 10.7270/Q28C9VCK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50071695 ((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity was evaluated against thrombin (FIIa) | Bioorg Med Chem Lett 8: 2501-6 (1999) BindingDB Entry DOI: 10.7270/Q28C9VCK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin-1 (Homo sapiens (Human)) | BDBM50071695 ((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity was evaluated against human trypsin cleavage of the chromogenic substrate | Bioorg Med Chem Lett 8: 2501-6 (1999) BindingDB Entry DOI: 10.7270/Q28C9VCK | |||||||||||
More data for this Ligand-Target Pair |