Found 3 hits for monomerid = 50072083 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072083
(CHEMBL3407929)Show SMILES OC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of KMO (unknown origin) |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072083
(CHEMBL3407929)Show SMILES OC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 mins |
Bioorg Med Chem Lett 27: 2023-2028 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.078 BindingDB Entry DOI: 10.7270/Q23R0W54 |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072083
(CHEMBL3407929)Show SMILES OC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 mins |
Bioorg Med Chem Lett 27: 2023-2028 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.078 BindingDB Entry DOI: 10.7270/Q23R0W54 |
More data for this Ligand-Target Pair | |