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SMILES: Clc1ccc(cc1Cl)-c1cc(ncn1)-n1cc[nH]c1=O

InChI Key: InChIKey=VSHASHJYPUERGY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50072113   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kynurenine 3-monooxygenase


(Homo sapiens (Human))		BDBM50072113
PNG
(CHEMBL3407894)
Show SMILES Clc1ccc(cc1Cl)-c1cc(ncn1)-n1cc[nH]c1=O
Show InChI InChI=1S/C13H8Cl2N4O/c14-9-2-1-8(5-10(9)15)11-6-12(18-7-17-11)19-4-3-16-13(19)20/h1-7H,(H,16,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Evotec (U.K.) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis

J Med Chem 58: 1159-83 (2015)


Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N
More data for this
Ligand-Target Pair